Streptomycin sensitivity of tubercle bacilli from resected lungs.

The sensitivity and resistance of tubercle bacilli to conteben (TB1/698).

prolonged employment of chemotherapeutic agents. The last decade was the most brillian period in the history of the battle against tuberculosis by chemotherapy. Streptomycin (SM), paraaminosalicylic acid (PAS), 4-acetylaminobenzaldehyde thiosemicarbazone (TB1) and isonicotinic acid hydrazide (INAH) have been proved to be effective in the treatment of tuberculosis. Among them, the resistance dev...

Development of streptomycin resistant strains of tubercle bacilli in pulmonary tuberculosis; results of simultaneous sensitivity tests in liquid and on solid media.

A series of cases of pulmonary tuberculosis has been treated with streptomycin under the auspices of the Medical Research Council. In some of the cases the antibiotic was given intermittently, a period of treatment alternating with a rest period. The results of this investigation will be published elsewhere. Sputa from a group of 18 of these patients treated at the Brompton Hospital, London, we...

Comparison of techniques for measuring the isoniazid resistance of tubercle bacilli.

As with streptomycin and P.A.S., the introduction of isoniazid for the treatment of tuberculosis has raised the problem of the development of resistance to the drug in strains of tubercle bacilli recovered from treated patients. In the Medical Research Council (1952) trials 71% of cultures from patients who had received three months' treatment with isoniazid alone were found to be resistant. Al...

Slide culture as a means of appraising the streptomycin sensitivity of tubercle bacilli in sputum.

Comments on bacterial resistance to streptomycin.

Shortly after streptomycin was introduced in the treatment of tuberculosis, two major obstacles to its value as a therapeutic agent became apparent. These were, vestibular damage and development of bacterial resistance. With the reduction in the daily dosage from 2 gm. and higher, to 1 gm. and later to 0.5 gm., serious vestibular damage has been eliminated. However, development of bacterial res...